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Reema Khan was born in 1971 in Multan, Pakistan.She was first spotted in 1990 by the Pakistani film director Javed Fazil, and was offered the supporting role in his film, Bulandi.
Khan started her film career in 1990 through Javed Fazil’s Bulandi.Khan's early films included Zherilay, Ishq, Naag Devta, Pyar Hi Pyar, Sailab, Dil, Aag, Shama and Sahiba. These were followed by films such as, Hina, Anjuman, Chakuri, Chandni, Neelam and Insaniat. Later she appeared in Hathi Meray Sathi directed by Shameem Ara, and in Rani Beti Raj Karegi directed by Altaf Hussain. In 2002, Asif Ali Pota’s Fire and Samina Peerzada’s Shararat were released. She was the first Pakistani actress to be signed by Pepsi Co., Pakistan for their series of advertisements.